Endothelial Shear Stress and Coronary Plaque Characteristics in Humans: A Combined Frequency-Domain Optical Coherence Tomography and Computational Fluid Dynamics Study

نویسندگان

  • Michail I. Papafaklis
  • Taishi Yonetsu
  • Christos V. Bourantas
  • Ioannis Andreou
  • Zhao Wang
  • James G. Fujimoto
  • Hang Lee
  • Luigi M. Biasucci
  • Filippo Crea
  • Charles L. Feldman
  • Peter H. Stone
چکیده

Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA Cardiovascular Division, Brigham & Women's Hospital, Harvard Medical School, Boston, MA Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands Department of Electrical Engineering and Computer Science, and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA Biostatistics Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA Department of Cardiovascular Medicine, Catholic University of the Sacred Heart, Rome, Italy Department of Cardiology, Medical School, University of Ioannina, Ioannina, Greece

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منابع مشابه

Endothelial shear stress and coronary plaque characteristics in humans: combined frequency-domain optical coherence tomography and computational fluid dynamics study.

BACKGROUND Despite the exposure of the entire vasculature to the atherogenic effects of systemic risk factors, atherosclerotic plaques preferentially develop at sites with disturbed flow. This study aimed at exploring in vivo the relationship between local endothelial shear stress (ESS) and coronary plaque characteristics in humans using computational fluid dynamics and frequency-domain optical...

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Low Endothelial Shear Stress Predicts Evolution to High-Risk Coronary Plaque Phenotype in the Future: A Serial Optical Coherence Tomography and Computational Fluid Dynamics Study.

BACKGROUND Low endothelial shear stress (ESS) is associated with plaque progression and vulnerability. To date, changes in plaque phenotype over time in relation to ESS have not been studied in humans. The aim of this study was to investigate whether local ESS can predict subsequent changes to plaque phenotype using optical coherence tomography. METHODS AND RESULTS A total of 25 coronary arte...

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BACKGROUND/AIM Practical difficulties, particularly long model development time, have limited the types and applicability of computational fluid dynamics simulations in numerical modeling of blood flow in serial manner. In these simulations, the most revealing flow parameters are the endothelial shear stress distribution and oscillatory shear index. The aim of this study was analyze their role ...

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High Risk Plaque Features on Coronary CTAngiography

Coronary computed tomography angiography (CCTA) is a non-invasive imaging technique that can detect, characterize and quantify coronary atherosclerotic plaques in routine clinical settings. The distinct morphological features of vulnerable plaques and stable lesions provide an opportunity for CCTA to identify high-risk plaque features and guide stratified therapeutic interventions. Morphologica...

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Optical Coherence Tomography for Patient-specific 3D Artery Reconstruction and Evaluation of Wall Shear Stress in a Left Circumflex Coronary Artery

Image-based computational models for quantifying hemodynamic indices in stented coronary arteries often employ biplane angiography and intravascular ultrasound for 3D reconstruction. Recent advances in guidewire simulation algorithms and the rise of optical coherence tomography (OCT) suggest more precise coronary artery reconstruction may be possible. We developed a patientspecific method that ...

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تاریخ انتشار 2014